منابع مشابه
Role of tetraspanin CD9 molecule in fertilization of mammals.
Fertilization process is a very clever and unique process comprising some essential steps resulting in formation of zygote. Tetraspanin CD9 is considered to be a serious candidate molecule participating in these events. The importance of CD9 has been discussed in relation to acrosome reaction, sperm-binding, sperm-penetration, sperm-egg fusion and eventually, egg activation. The abundant expres...
متن کاملTetraspanin CD9 in cell migration.
Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) an...
متن کاملHEMATOPOIESIS CD9 and megakaryocyte differentiation
It is shown that the tetraspanin CD9 has a complex pattern of distribution in hematopoietic cells and is heterogeneously expressed on human bone marrow CD341 cells. CD34highCD38lowThy11 primitive progenitors are contained in the population with intermediate CD9 expression, thus suggesting that CD9 expression may precede CD38 appearance. Cell sorting shows that colony-forming unit (CFU)GEMM and ...
متن کاملMolecular cloning and characterization of chick CD9.
CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, growth signaling and tumor cell metastasis. In this study a CD9 cDNA clone has been isolated from chick cDNA library. The chick CD9 clone contains an open reading frame of 224 amino acids. The deduced amino acid sequence from chick CD9 shows 63.3% identity with the human counterpart. Human and monkey CD9 upregul...
متن کاملDirect binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion.
The function currently attributed to tetraspanins is to organize molecular complexes in the plasma membrane by using multiple cis-interactions. Additionally, the tetraspanin CD9 may be a receptor that binds the soluble ligand PSG17, a member of the immunoglobulin superfamily (IgSF)/CEA subfamily. However, previous data are also consistent with the PSG17 receptor being a CD9 cis-associated prote...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44793